-
-
New TRR publication! Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus.
Antagonistic bacterial interactions often rely on antimicrobial bacteriocins, which attack only a narrow range of target bacteria. However, antimicrobials with broader activity may be advantageous.…
More -
New TRR paper! Fosfomycin Uptake in Escherichia coli Is Mediated by the Outer-Membrane Porins OmpF, OmpC, and LamB
The antibiotic fosfomycin (FOS) is widely recognized for the treatment of lower urinary tract infections with Escherichia coli and has lately gained importance as a therapeutic option to combat…
More -
New TRR publication! Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A
Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A
The caseinolytic protease is a highly conserved serine protease, crucial…
More -
PhD fellowship in “Molecular Mechanisms of Antibacterial Action and Resistance of Novel Antibacterial Agents”
PhD fellowship in “Molecular Mechanisms of Antibacterial Action and Resistance of Novel Antibacterial Agents” at the Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology…
More -
New paper! An antibiotic from an uncultured bacterium binds to an immutable target
Antimicrobial resistance is a leading mortality factor worldwide. Here, we report the discovery of clovibactin, an antibiotic isolated from uncultured soil bacteria. Clovibactin efficiently kills drug-resistant…
More -
New paper! Molecular Characterization of the ClpC AAA+ ATPase in the Biology of Chlamydia trachomatis
Chlamydia trachomatis is an obligate intracellular pathogen and the…
More -
Kinder-Uni-Forschungstag: Das Unsichtbare sichtbar machen: Mikrobiologie Mitmach-Workshop im Schloss
Gemeinsam mit Wissenschaftlern des Exzellenzclusters CMFI und TRR261 wurde am ersten Juli das Unsichtbare sichtbar! Im Rahmen des Workshops wurden einfache Techniken aus dem Zell- und Mikrobiologielabor…
More -
New TRR paper! Identification of macrocyclic peptides which activate bacterial cylindrical proteases
The caseinolytic protease complex ClpXP is an important house-keeping enzyme in prokaryotes charged with the removal and degradation of misfolded and aggregated proteins and performing regulatory proteolysis.…
More -
International Conference TRR261, 22-25 May, 2023 in Bad Boll
We enjoyed the excellent talks and posters, great science and unforgettable networking!
Many thanks to all participants for the amazing…
More
